OVERVIEW

We are seeking a talented Protein Engineer with hands-on experience in antibody/protein design to join the highly productive Protein Engineering group within Sanofi US Biologics Research. The position will work closely with experienced scientists in a dynamic, fast-paced and highly collaborative environment. Protein Engineering group has a great track record of patent and publication in the area of Fc engineering and multispecific antibodies. We have a state-of-art structure biology capability within the group, offering a unique opportunity to collaborate closely on Protein Engineering projects. This individual will play a key role in design and implementation of Yeast Display Campaigns for engineering of affinity, developability, epitope mapping etc. He/She will also represent Biologics Research Department in cross-functional project teams under minimal supervision. Previous experiences with YSD technology highly desired. Previous experience with multispecifics-antigen interaction is a plus.

RESPONSIBILITIES

• Design and implement antibody screening campaigns using YSD technology for various antibody engineering efforts. Including, but not limited to, affinity tuning, pH-dependent protein-protein interactions, liability/developability engineering and fast epitope mapping.

• Develop and optimize assays to screen the engineered biotherapeutics for improved biological properties, binding affinity and biophysical characteristics

• Documenting and presenting experimental results, conclusions and interpretations at departmental and cross-functional project team meetings

• Write scientific publications and present at conferences. Contribute to patent applications.

• Represent Biologics Research (BR) Department in cross-functional project teams, coordinate/lead the BR activities, and work closely together with the Therapeutic Area Project Lead for milestone transitions.

QUALIFICATIONS

• Ph.D. in biologic sciences, molecular cell biology, protein engineering, or similar, with 0-3 years of research experience in academia and/or Biotech/Pharmaceutical environment, in Biochemistry/ Bioengineering/ Structural Biology or a related discipline.

• Self-motivated and highly collaborative to work in a cross-cultural, multidisciplinary, team-oriented environment with excellent communication and organization skills

• Expertise in strategizing, designing and performing YSD campaigns.

• Well-versed in protein engineering technologies and principles, including antibody/protein structure-function relationships, biophysical/biochemical analysis; Proven experience in antibody/protein design.

• Familiarity in a wide range of screening assays and analytical methods, such as ELISA, ALPHAScreen, Octet, Biacore, HPLC, DSC/DSF, MALS ; Experience with high-throughput analytical methods is a plus.

• Track record of scientific accomplishments as evidenced by a strong publication record

• People management experience preferred, but not required

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.